Medications Used for the Treatment

Thanks to advances in pharmaceutical technology, many new and effective drugs are available today in the field of infertility. These drugs aim to increase the pregnancy rate by ensuring development of adequate size and number of follicles. Obtaining more than one follicles especially in assisted reproductive techniques (such as IVF, ICSI) is one of the most important factors for success. Hormones called FSH (follicle stimulating hormone) and LH (luteinizing hormone), which are responsible for egg production in women, are used for ovarian stimulation.


Clomiphene, which increases FSH release, is one of the first drugs that are being used for the treatment of infertility. The drug, sold in the form of tablets, are generally used between the 5th and 9th days of the menstrual cycle and may ensure development of multiple follicles in ovaries.

Human Menopausal Gonadotropins (HMG)

The drug, containing both FSH and LH hormones which are obtained by purifying urines of post-menopausal women, is administered for ovarian stimulation and obtaining multiple follicles for IVF and ICSI. This drug is used as a daily subcutaneous injection.

Urinary FSH

The drug, containing only FSH hormone which are obtained by purifying urines of post-menopausal women, is used for ovarian stimulation and obtaining multiple follicles for IVF and ICSI and administered as a daily subcutaneous injection.

Recombinant FSH

Recombinant FSH preparations are 100% pure and produced through genetic engineering laboratory conditions. Recombinant FSH is intended to production of more than one eggs for IVF and ICSI by ensuring multiple follicles through ovarian stimulation. The drug, administered as a subcutaneous injection, is now available in the form of a pen that makes dose adjustment automatically.

Gonadotropin Releasing Hormone Agonists (GnRHa)

These agonists are the synthetically-derived form of the gonadotropin-releasing hormone which helps release of FSH and LH hormones from the pituitary gland and is released from the center called hypothalamus in the brain. These are also available in injection or nasal spray forms.

Early increase in the LH (Luteinizing Hormone) is one of the major problems for the treatment with assisted reproductive techniques. This leads hatching of the eggs before the estimated duration and decrease the chance of obtaining sufficient number and quality of eggs. As the administration of GnRH agonists prevents such early increase in the LH hormone released during the hormonal ovarian stimulation, it minimizes the chance of obtaining eggs with less number and low quality. This is no longer is used for treatments at our clinic.

GnRH Antagonists

Even though it has the same effect with the GnRH antagonists functionally, this reduces the number of days that the patients are required to come to the clinic and thus, reduces the cost of the treatment as its effect and usage is shorter, Low number of injections is another advantage with this drug. 0.25 mg daily form of the drug is administered starting from the 6th of the stimulation and continued until the egg development is complete.

Human Chorionic Gonadotrophin (hatching injection)

This is injected approximately 35-36 hours before egg retrieval, and follicle hatching occurs approximately 36-38 hours after this injection and the eggs are released. The effect of this hormone is to mature and prepare the eggs in grown follicles to fertilization and induce progesterone release. These medications, similar to LH, a natural hormone, ensure hatching of the eggs in women. The HCG injection timing is very important and it must be made at the specified time.


If this hormone which is necessary for healthy growth and development of the layer of the endometrium lining the inside of the uterus and where the fertilized egg is placed cannot be released sufficiently, healthy placement of the embryo into the endometrium will not be possible. Therefore, this hormone is administered externally in order to support the endometrium in the IVF and ICSI procedures. The treatment called luteal phase support is administered as a vaginal suppository or gel. In our clinic, vaginal capsule administration is given 3 times a day as 1 each ovule on the day of egg retrieval process and continued untl the pregnancy test. If the pregnancy test is positive, this will be continued in the form of vaginal ovule until the 8th week of the pregnancy. The progesterone preparations given in our clinic are natural and do not contain any side effect on pregnancy.


This drug, used for patients for which the egg development will be difficult, is given between the 2th and 4th days of the menstrual cycle and used for a total of 5 days as 2 tablets per day. If egg development cannot be achieved, this drug can be used for 3 to 4 consecutive menstrual periods.

Other Medications
  • Tetra 500 Capsule: Tetra, administered as a preservative for preventing possible infections in female reproductive system to interfere with the occurrence of pregnancy, is an antibiotic. Tetra is started on the day of the egg retrieval and continued for a period of 4 days.
  • Prednol 16 mg Tablet: The use of this drug, used in order to prevent the possible refusal reaction to the immune system that may develop during the occurrence of pregnancy, is started on the day of the egg retrieval and continued for a period of 4 days. Prednol is used as a single dose at bedtime.
  • Folic acid (Folbiol or Centrum): This is a vitamin that is given daily from the start of the treatment in order to prevent the emergence of disabled infants.
  • Parlodel SRO Capsule: This drug, which is administered to patients with a high prolactin hormone, should be taken after dinner.
  • Luveris Ampoule: This LH-containing drug is used for some patients, and the dosage and usage will be determined and delivered to you by your physician.

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