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Unmedicated In Vitro Fertilization (IVF)

What Is Unmedicated In Vitro Fertilization?

In the conventional in vitro fertilization treatment, eggs are collected and processed after maturation. In in vitro maturation (IVM) treatment, eggs collected without full maturation are subjected to in vitro maturation. The purpose of this treatment is to apply the treatment of patients without medication in case such medication is likely to damage the patient, in order to protect the patient’s body. The patient is given none or too little hormones during the in vitro maturation treatment.  Egg growth is monitored until they reach the required size; then they are collected with needle under general anaesthesia and these eggs are kept in certain media until maturation under laboratory conditions. In the next step, sperm retrieved from male spouse is injected into the eggs with microinjection  method and embryos are transferred back to the uterus in the final step

.Who should prefer IVF?

It was observed that certain patients are sensitive against medication used for in vitro fertilization and such sensitivity could cause oedema in the abdomen and lungs (ovarian hyperstimulation syndrome- OHSS) due to unexpected, excessive response of the ovaries.  In vitro maturation treatment is preferred particularly with PCOS (Polycystic Ovary Syndrome) patients with high risk of OHHS development due to this sensitivity.  Further, it can also be used with endometriosis patients, patients with low response to medication and in case of male infertility.  In vitro maturation treatment is an ideal method particularly for patients who are prohibited to have hormone treatment. 

What are the advantages?

  • Easier treatment
  • Shorter treatment duration (8 to 10 days)
  • No side-effect
  • No complication
  • Less clinic visits (1 to 2 times)
  • Less injection (2 to 3 times)
  • No bloodletting
  • Low drug cost

What are the disadvantages?

Inability to obtain the desired quality of eggs at all times and slightly lower pregnancy rates.

Who Are Not Eligible?

The treatment is not suitable for elderly patients.

What is the Success Rate?

IVM pregnancy rates are within acceptable limits (30%).

What is the duration of treatment?

Total duration of the IVM treatment is 8 to 10 days, and duration that our patients are required to spend at our clinic during the treatment is half an hour for each visit which is in total 1 to 2 times.

What is the cost?

The cost of the treatment is same as the conventional IVF treatment, but discount in medication costs up to 90% is available.

Is this method currently used as a common method in Turkey?

This method of treatment can be provided by a small number of IVF centers in the world and in Turkey.


Unmedicated In Vitro Fertilization

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