Preimplantation Genetic Diagnosis (PGD)

With the Preimplantation Genetic Diagnosis (PGD), recently introduced to today's IVF treatment, patient or healthy carrier couples can have a baby. Embryos derived from fertilization of eggs by sperms during IVF treatment can be controlled against many familial and chromosomal diseases before transfer into the uterus with 1 or 2 pieces of tissue (blastomeres) sampling.

Couples with chromosomal or genetic diseases can have a healthy baby with the treatment of IVF and following PGT implementation to embryos developed even if they do not have problems such as infertility. This procedure includes testing of 1 or 2 pieces of tissue sampling from sperm from embryos formed by fertilization of sperm from father and egg from mother during in vitro fertilization treatment and transferring of embryos determined to be healthy into the uterus.

PGD procedure is recommended for diseases that are familial inherited and can not be treated after birth. The first PGD baby was born in October 2000 in the United States. In that pregnancy, the only healthy one from about 15 embryos was selected using the PGD and transferred.

PGD ​​procedure, launched at the end of the 90s in Europe and America, is used in our clinic for patients deemed necessary. If recurrent miscarriages, failed IVF attempts, advanced age, genetic or chromosomal disease (disease or carrier) in one of partners exist, the use of PGD method is recommend. With this method, healthy and genetically disease-free embryos are selected and transferred. For example, occurrence of the disease of ornithine carbamyl transferase deficiency that is inherited to baby from mother depending on X chromosome and causes liver disorder can be avoided by choosing those, which do not carry this disease, from among embryos developed during the treatment of IVF and transferring into the uterus.

Today, muscular diseases, such as hemophilia, Duke and neuromuscular dystrophy, and Tay-Sachs, cystic fibrosis, sickle cell anemia, and fragile X syndrome, Down syndrome and other chromosomal disorders can be diagnosed with the PGD method.

Result of the PGD method, performed without damage to embryos, can be obtained within 24 hours. This method can be performed in 3 ways:

  • Polar body biopsyovary from mother's ovaries (oocyte) (can detect diseases which belongs to the mother alone)
  • Tissue sampling (blastomere biopsy) taken from 3-day embryo (6-8 cells). (most common method in practice.)
  • Tissue sampling (blastocyst biopsy) taken from 5-day embryo The so-called array CGH method is used today for genetic diagnosis and thus, all of 46 human chromosome can be identified numerically.

Researches conducted in order to detect diseases, such as cardiovascular diseases, diabetes, hypertension considered to be genetically inherited, and cancers in the future with the PGD and completely eliminate these diseases for future generations continue.

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Dr. Hakan Özörnek'in kaleme aldığı "Bebek İstiyorum" kitabını ücretsiz olarak indirmek için kayıt olabilirsiniz.

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